We all like a story with a feel good ending.
Here is the story of the three little tablets and the Big Bad Humidity.
There once were three little tablets that had just graduated from R&D with their DSC, TGA and DVS, ready to start their journey out into the big wide world. One of the little tablets even graduated from R&D with honours in high amorphous content. In the beginning they were well made up, and in their API hearts, very happy with their polymorphic state.
The first little tablet built its home in the wrong season of the year. To make matters worse, climate change made it almost impossible to find any part of the year to be safe. Along came Big Bad Humidity and said “I will adsorb, and adsorb, and adsorb moisture on to you little tablet”. Before long, the first little tablet’s API heart was broken into pieces and the R&D doctor diagnosed chronic hydrolysis. That was the end of life on the shelf for the first little tablet.
The second little tablet built its home more soundly and had the wisdom to wear a moisture barrier film coat. But things change, as they often do, and the second little table changed its coat for a new TiO2-free coat. Along came Big Bad Humidity and said “I will adsorb, and adsorb, and adsorb moisture on to you little tablet”. Poor second little tablet was soon very alone because nobody wanted a tablet that had become all squidgy inside. Second little tablet had to be recalled back to where it was born, and the R&D doctor was sacked.
The third little tablet built its home in a different way. Clever third little tablet monitored what was happening with Big Bad Humidity. Third little tablet went to a Relequa® Moisture Profiling™ clinic and learned where Big Bad Humidity was weak. Along came Big Bad Humidity and said “I will adsorb, and adsorb, and adsorb moisture on to you little tablet”. But third little tablet simply ignored Big Bad Humidity and lived happily ever after in humidity equilibrium to the end of its good shelf life.
And the moral of the story is?
Be in control of moisture at all times.
I write about how humidity and moisture effects everything around us. If you would like to hear more on the impact of moisture, various topics on moisture and humidity are discussed in my eBook “A Wetter Look At Climate Change”.